Proton pump inhibitors decrease eotaxin-3/CCL26 expression in patients with chronic rhinosinusitis with nasal polyps: possible role of the nongastric H, K-ATPase
JY Min, CJ Ocampo, WW Stevens, CPE Price… - Journal of Allergy and …, 2017 - Elsevier
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is often characterized by
tissue eosinophilia that is associated with poor prognosis. Recent findings that proton pump
inhibitors (PPIs) directly modulate the expression of eotaxin-3, an eosinophil
chemoattractant, in patients with eosinophilic diseases suggest therapeutic potential for PPIs
in those with CRSwNP. Objective We assessed the effect of type 2 mediators, particularly IL-
13 and eotaxin-3, on tissue eosinophilia and disease severity in patients with chronic …
tissue eosinophilia that is associated with poor prognosis. Recent findings that proton pump
inhibitors (PPIs) directly modulate the expression of eotaxin-3, an eosinophil
chemoattractant, in patients with eosinophilic diseases suggest therapeutic potential for PPIs
in those with CRSwNP. Objective We assessed the effect of type 2 mediators, particularly IL-
13 and eotaxin-3, on tissue eosinophilia and disease severity in patients with chronic …
